Ambrisentan (Letairis)
School Resource Guide

Download the Ambrisentan (Letairis) pdf

Ambrisentan is a medication used to treat pulmonary arterial hypertension, which is a type of high blood pressure in the lungs that affects heart function.

Ambrisentan works by relaxing the blood vessels, which decreases pressure and improves heart function.

How it’s administered

Ambrisentan is an oral medication given once daily.

Tablet must be swallowed whole. Do not split, crush or chew tablets.

Can be taken with or without food.

Dosing: 5 mg and 10 mg tablets. It is available as a generic drug. Tablets shape and color may vary depending on manufacturer.

Common side effects

  • Swelling of the lower extremities
  • Nasal congestion
  • Sinusitis
  • Flushing
  • Irregular heartbeat
  • Abdominal pain and constipation
  • Headache

If the student has shortness of breath, palpitations or swelling of the legs, hands or face, seek immediate medical assistance. Headache, flushing, itching, rash, upset stomach or nasal congestion should be treated as advised by the student’s physician.

Additional information

The student may be absent from school for mandatory monthly blood tests to monitor this medication.