Selixipag (Uptravi)
School Resource Guide

Download the Selixipag (Uptravi) pdf

Selexipag is a medication used to treat pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs, which affects heart function. Selexipag works by relaxing blood vessels in the lungs, which decreases pressure and improves heart function.

How it’s administered

  • Selexipag is a tablet taken by mouth.
  • It usually is taken twice a day.
  • Tablet should be swallowed whole. Do not crush, split or chew.
  • Can be taken with or without food. Taking with food may help improve tolerability.
  • Available in several dosages that physicians can adjust to improve efficacy.


Selixipag dosing starts at 200 mcg twice a day. The dosage can be increased by 200 mcg twice a day every week to maximum tolerated dose, up to 1600 mcg twice a day.

If a student misses a dose, they should take the missed dose as soon as possible unless the next scheduled dose is within six hours. The student may experience minor side effects, such as mild flushing or loose stools. If symptoms or side effects are severe, or you are concerned about other side effects the student may be having, contact the student’s parents or emergency contact immediately.

Common side effects

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea/vomiting
  • Arm or leg pain
  • Flushing
  • Joint pain
  • Low red blood cell count
  • Decreased appetite
  • Rash

Additional information

Loperamide/Imodium can be used for diarrhea.

Tylenol may be used for headache.

If the student takes more than the prescribed dosage, call 911 immediately.