Treprostinil (Orenitram)

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Treprostinil (Orenitram) is a medication used to treat pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs that affects heart function. Orenitram works by relaxing blood vessels in the lungs, which decreases pressure and improves heart function.

How it’s administered

Orenitram is available in five strengths:

  • White 0.125 mg tablet
  • Green 0.25 mg tablet
  • Yellow 1 mg tablet
  • Pink 2.5 mg tablet
  • Red 5 mg tablet

Orenitram is taken two or three times a day, depending on the prescription prescribed. Don’t take two doses at the same time.

Always take this medication with food. Swallow tablets whole. Do not crush, split or chew.

If a student misses a dose, they should take the missed dose with food as soon as possible unless it’s close to the time for the next dose. If it’s close to the time for the next dose, skip the missed dose and go back to the usual time. Don’t take two doses at the same time. Don’t take extra doses.

Medication typically starts at 0.125 mg two or three times a day. It’s increased by 0.125mg every two to four weeks if there are no side effects. There is no known upper dose limit.

Side effects

  • Headache
  • Pain in jaw
  • Diarrhea
  • Pain in arm(s) or leg(s)
  • Nausea
  • Abdominal discomfort
  • Flushing

Students might have minor side effects, such as mild flushing or loose stools, all the time. If side effects are severe, or if you are concerned about other side effects the student might be having, contact the student’s parents or emergency contact.

If student is dizzy or passes out, it may be due to low blood pressure. This requires urgent medical attention.

Additional information

If the student misses two or more doses, notify the parent as soon as possible. The student’s pulmonary hypertension specialist must be contacted.

The tablet shell isn’t digested, so the tablet shell can be seen in the feces. This is normal.

Loperamide/Imodium can be used for diarrhea and Tylenol for headache.