PHCC – Houston Methodist 2017-11-02T18:46:36+00:00
PH Care Centers

Houston Methodist Hospital

Houston Methodist Pulmonary Hypertension Program
6445 Main St.
Houston, TX 77030

Phone: (713) 441-7779

PHA Centers of Comprehensive Care


The Pulmonary Hypertension (PH) program at the Houston Methodist Hospital was established in the 1990’s by Dr. Adaani Frost as an outgrowth of the lung transplant program. It was the result of a request by Drs. Lewis Rubin and Stuart Rich for this site to facilitate enrollment in a PH study. Dr. Zeenat Safdar joined the program after completing her clinical and research training and currently serves as the director of the program. This PH program has grown to be a major center for the conduct of clinical trials and a provision of state of the art care to pulmonary hypertension patients. It serves as a referral center for the local community physicians in and around the Houston area. In addition, the referral base for this program draws from a large catchment area including more remote parts of Texas, Arkansas, Louisiana, Oklahoma and other surrounding states, as well as Central and South America. Originally this program was a combined program of Houston Methodist Hospital and Baylor College of Medicine, however, since 2015 this program has moved in its entirety to Houston Methodist Hospital.

The PH physicians have extensive experience in managing complex PH patients and collaborate with various specialties, including rheumatology, hepatology, heart failure cardiology, anesthesiology, palliative care and solid organ transplant. In addition, there is an inpatient ward with dedicated hospital floors for PH patients, a dedicated pharmacist, and trained clinical nurses and respiratory therapist.

Since its inception, this center has participated in a large number of multicenter clinical trials, many of which led to the development and approval of many therapies. As a leading PH program, more than 60 PH studies have been completed, 10 PAH studies are ongoing and several other are in the pipeline at this site. This places the program at the forefront of cutting edge research.

PH Program Physicians

  • Zeenat Safdar, MD
  • Adaani Frost, MD
  • Sandeep Sahay, MD
  • Myung Park, MD
  • Guha Ashrith, MD

Center Coordinators

  • Royanne Holy, RN
  • Allie DeHart, RN
  • Salino Ann, RN
  • Jennifer Lee
  • Gwendolyn Goodloe
  • Adoura Emmanuel

Duration of Program’s Existence

  • Since 1993

Number of PAH Patients Being Actively Managed

  • >350

Number of Patients on IV/SQ Therapy

  • 70-79

Support Services Available

  • Anticoagulation Services
  • Cardiac Anesthesia
  • Central Line Placement/Repair
  • Congenital Heart Disease
  • Dietary/Nutrition Services
  • Lung Transplant Program
  • On-call Pulmonary/Cardiology Service (24/7 Availability)
  • Palliative Care
  • Pulmonary or Cardiac Rehabilitation
  • Pulmonary Thromboendarterectomy (PTE)
  • Social Work
  • Rheumatology
Zeenat Safdar, MD, MS

Zeenat Safdar, MD, MS

Board Certifications

  • Internal Medicine, Pulmonary Diseases, Critical Care Medicine


  • 1984 – HSC – Biology, St. Joseph’s College, Karachi, Pakistan
  • 1991 – MBBS/MD – Sind Medical College, Karachi University, Karachi, Pakistan
  • 2015 – MS – Clinical Investigation, School of Biomedical Sciences, Baylor College of Medicine, Houston, TX

Postgraduate Training

  • 1994 – Intern, Jinnah Post Graduate Medical Center, Karachi, Pakistan
  • 1998 – Resident, State University of New York Health Center, Brooklyn, NY
  • 2002 – Fellow, St. Luke’s Roosevelt Hospital Center, Mount Sinai, New York, NY
  • 2005 – Research Fellow, Columbia University College of Physicians and Surgeons, New York, NY

Current Hospital and Administrative Appointments

  • 2015-Present – Adjunct Associate Professor, Pulmonary/Critical Care and Sleep Division, Department of Medicine, Baylor College of Medicine, Houston, TX
  • 2015-Present – Director, Pulmonary Hypertension Program, Houston Methodist Hospital, Houston, TX
  • 2015-Present – Director of Clinical Research, Houston Methodist Lung Center, Houston, TX

PH-Specific Activities

  • Fellow, American College of Physicians
  • Fellow, American College of Chest Physicians
  • Member, American Physiological Society
  • Member, American Thoracic Society
  • Fellow, Pulmonary Vascular Research Institute
  • Member, International Society for Heart & Lung Transplantation
  • Member, Pulmonary Hypertension Clinicians and Researchers
  • Member, Institute for Clinical and Translational Research

Awards & Honors

  • 2004: Empire Clinical Research Investigator’s Award
  • 2010–2015: Development Award, NHLBI-NIH
  • 2011: Academy of Distinguished Educatiors, Baylor College of Medicine
  • 2011–2012: Award for Teaching and Evaluation, Fulbright & Jaworski LLP Faculty Excellence


  • Click here for recent pulmonary hypertension publications by Dr. Safdar.

Royanne E. Holy, RN, BSN

Professional Credentials

  • Registered Nurse


  • 1993 – BSN – University of Calgary, Calgary, Alberta, Canada

Current Professional Experience

  • 2015–Present – Clinical Coordinator, Houston Methodist Pulmonary Hypertension Program, Houston, TX

PH-Specific Activities

  • PH Professional Network

New patients interested in making an appointment with the Houston Methodist Pulmonary Hypertension Program can request an appointment by calling:

  • Phone: (713) 441-7779

Last Verified: July 28, 2016