Pulmonary Vascular Disease Phenomics (PVDomics)

Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics is a multi-center initiative to understand individual differences among people with pulmonary hypertension. By identifying biomarkers, the PVDomics project aims to improve PH diagnosis and treatment.

The observational study was funded by the National Heart, Lung and Blood Institute with support from the Pulmonary Hypertension Association. Researchers collected information from about 1,000 people with various types of PH and 500 people without or at risk for PH.

The study performed comprehensive phenotyping for all types of PH. Since then, researchers have published more than 20 papers based on data from the study. See links to PubMed abstracts.

The projects hopes to deconstruct traditional PH classifications and define new sub-groups of PH. Ideally, the new sub-classifications would lead to more targeted screening and personalized approaches for treatment, care and prevention of pulmonary vascular disease.

Participating centers

Cleveland Clinic (data coordinating center)

Brigham and Women’s Hospital, Boston
Jane A. Leopold, MD, principal investigator

Columbia University-New York Presbyterian
Erika S. Berman Rosenzweig, MD, principal investigator

Weill Cornell Medicine-New York Presbyterian
Evelyn Horn, MD, principal investigator

Johns Hopkins University
Paul Hassoun, MD, principal investigator

Mayo Clinic
Robert P. Frantz, MD, principal investigator

University of Arizona
Franz Rischard, DO, principal investigator

Vanderbilt University
Anna Hemnes, MD, principal investigator

More information

PHA interview with Jane Leopold

Project details (NIH)

Study protocol (Cleveland Clinic)

Apply by March 1, 2024, to access clinical data (Cleveland Clinic) Cleveland Clinic Center for Continuing Education Pulmonary Hypertension Series webcast.

Related content

New Papers Show How PVDomics Is Redefining PH Classifications

2022 Focus on Pulmonary Hypertension Research

Researcher Seeks Clues Within PH Classifications