Dr. Robyn J. Barst Pediatric PH Research and Mentoring Fund Grant Winner 2013

Mehdi Fini, MDMehdi Fini, MD

Instructor in the Divison of Pulmonary and Critical Care
University of Colorado Denver
Title: “Role of Xanthine Oxidoreductase-Uric Acid Axis in Hypoxia Induced Pulmonary Hypertension”
Term: December 1, 2013 through November 30, 2014

This Barst Fund Award was made possible through a generous, anonymous donation in honor of pediatric PH patient Cordelia.


Summary of Research Project:

There are currently few prognostic and therapeutic options for pediatric patients with PH. However, preliminary research indicates that uric acid level may be a valid biomarker for predicting risk of PH-associated death in children, and some studies have found an association between high uric acid blood concentration and probability of a PH diagnosis in both children and adults. In the current project, Dr. Fini will investigate uric acid’s usefulness as a biomarker of disease onset and progression. He will also examine whether or not reducing uric acid can be used to treat PH. Dr. Fini will conduct his study using a novel genetic model which could ultimately improve the management of pediatric patients with PH.