Dr. Robyn J. Barst Pediatric PH Research and Mentoring Fund Grant Winner 2018

Michael L. O’Byrne, M.D., MSCE
Assistant Professor – CE (Pediatrics)
Children’s Hospital of Philadelphia
Title: “Multidimensional evaluation of health-related quality of life in pediatric pulmonary hypertension”
Term: Dec. 1, 2018 – Nov. 30, 2019

London A. Lotarski Pediatric PH Research & Mentoring Grant

Summary of Research Project:

Historically, pulmonary hypertension (PH) in children was associated with dramatically shorter lifespans. Drug development has reduced this risk, but children with PH experience chest pain, exercise intolerance, and fainting spells that are an obstacle to participating in and enjoying the activities that define childhood. PH symptoms, chronic drug treatment and intense follow-up are all stresses on patient and family. The effect of this on children with PH has not been studied, as it is not recorded in doctors’ notes or in clinical trials. Patient-reported outcomes (PRO) identify aspects of the patient experience that are informative about health and are expressed in terms that make sense to and are important to patients and their families. PRO can then be measured and used in both research and clinical care. Health related quality of life (HRQOL) is one such PRO, measuring whether a person can participate in and enjoy age appropriate activities. Having more severe PH (and more severe symptoms) likely reduces HRQOL, but other factors likely also influence it. These are 1) presence of anxiety or depression, 2) patient’s outlook on life (in terms of optimism and resilience), and 3) parental stress levels. These factors can be measured with research questionnaires and combined with data collected during routine medical care to provide a complete assessment of the factors influencing HRQOL. We plan to study which of these factors affects HRQOL in a group of children with PH. Identifying factors that influence HRQOL is important because, doing so might make it possible to intervene on one or more of them and improve the health and well-being of children with PH, independent of the severity of the child’s disease.

Curriculum Vitae


2005-2006 Doris Duke Clinical Research Fellow, Columbia University College of Physicians and Surgeons, New York City, NY

2015-2017 Interventional Cardiologist, Children’s National Medical Center, Washington, DC

2015-2017 Assistant Professor of Pediatrics, George Washington University School of Health Sciences, Washington, DC

2017- Interventional Cardiologist, Children’s Hospital of Philadelphia, Philadelphia, PA

2017- Assistant Professor of Pediatrics University of Pennsylvania Perelman School of Medicine, Philadelphia PA

2017- Core Faculty, Center for Pediatric Clinical Effectiveness, Children’s Hospital of Philadelphia, Philadelphia, PA

Honors and Awards

2006 AOA Debbie Glaser Medical Student Essay Contest: Honorable Mention

2007 Arnold P. Gold Humanism Honor Society

2007 Rebecca Schwartz Prize in Pediatric Cardiology (Columbia University)

2007 Marie Nercessian Award for Compassionate Care of Patients (Columbia University)

2010 Senior Resident Clinician Award (Children’s Hospital of Philadelphia graduation award for excellence in clinical care)

2017 Christopher J White, MD Early Career Reviewer Award (Catheter Cardiovasc Interv for “expertise in providing constructive evaluation and critical comments… in the field of interventional cardiology)

2018 American Heart Association Council of Cardiovascular Disease in the Young: Young Investigator Award Finalist (with winner to be determined at AHA Scientific Sessions in November 2018).

Research Support

2016-2021: NIH/NHLBI K23

2017-2020: Cardiac Center, The Children’s Hospital of Philadelphia, Cardiac Center Development Grant

2017-2020 ACC/NCDR NCDR-funded analysis of IMPACT registry

Selected Publications

O’Byrne ML, Mercer-Rosa L, Ingall E, McBride MG, Paridon S, Goldmuntz E. Habitual Exercise Correlates With Exercise Performance in Patients with Conotruncal Abnormalities. Pediatr Cardiol 2012, 34: 853-860. PMID: 23104594.

O’Byrne ML, Mercer-Rosa L, Zhao H, Zhang X, Yang W, Cassedy A, Fogel MA, Rychik J, Tanel RE, Marino BS, Paridon S, Goldmuntz E. Morbidity in children and adolescents after surgical correction of truncus arteriosus communis. Am Heart J 2013, 166(3): 512-518. PMCID: PMC3771390.

O’Byrne ML, Mercer-Rosa L, Zhao H, Zhang X, Yang W, Tanel RE, Marino BS, Cassedy A, Fogel MA, Rychik J, Paridon S, Goldmuntz E. Morbidity in Children and Adolescents Following Surgical Correction of Interrupted Aortic Arch. Ped Cardiol 2014, 35(3): 386-392. PMCID: PMC3943951.

O’Byrne ML, Desai S, Lane M, McBride M, Paridon S, Goldmuntz E. 2017. Relationship Between Habitual Exercise and Performance on Cardiopulmonary Exercise Testing Differs Between Children With Single and Biventricular Circulations. Pediatr Cardiol, 38(3): 472-483. PMCID: PMC5357181.

O’Byrne ML, Glatz AC, Shinohara RT, Jayaram N, Gillespie MJ, Dori Y, Rome JJ, Kawut S. Effect of center catheterization volume on risk of catastrophic adverse event after cardiac catheterization in children. Am Heart J 2015, 169(6): 823-832 PMCID: PMC4451573.

O’Byrne ML, Glatz AC, Hanna BD, Shinohara RT, Gillespie MJ, Dori Y, Rome JJ, Kawut SM. Predictors of Catastrophic Adverse Outcomes in Children With Pulmonary Hypertension Undergoing Cardiac Catheterization: A Multi-Institutional Analysis From the Pediatric Health Information Systems Database.. J Am Coll Cardiol 2015, 66(11): 1261-1269 PMCID: PMC4567688.

Jayaram N, Spertus JA, O’Byrne ML, Chan PS, Kennedy KF, Bergersen L, Glatz AC. 2017. Relationship Between Hospital Procedure Volume and Complications Following Cardiac Catheterization: A Report from the IMPACT® Registry. 183: 118-128. PMCID: PMC5179039.

O’Byrne ML, Kennedy KF, Berger JT, Kanter JP, Glatz AC. 2018. Risk factors for major early adverse events related to cardiac catheterization in children and young adults with pulmonary hypertension: An analysis of data from the Improving Adult and Congenital Treatment® (IMPACT®) Registry. J Am Heart Assoc, 7(5). e-published ahead of print. PMCID: PMC5866335.

O’Byrne ML, Glatz AC, Song L, Griffis HM, Millenson ME, Gillespie MJ, Dori Y, DeWitt AG, Mascio CE, Rome JJ. 2018. Association Between Variation in Preoperative Care Before Arterial Switch Operation and Outcomes in Patients with Transposition of the Great Arteries: Analysis of Data from the Pediatric Health Information Systems Database. Circulation, in press. PMCID: Pending.

Glatz AC, Kennedy KF, Rome JJ, O’Byrne ML. 2018. Variations in practice patterns and consistency with published guidelines for balloon aortic and pulmonary valvuloplasty: An analysis of data from the IMPACT® Registry. JACC Cardiovasc Intervent, 1(6):529-538. PMCID: Pending

O’Byrne ML, Kim S, Hornik CP, Yerokun BA, Matsouaka RA, Jacobs JP, Jacobs ML, Jonas RA. 2018. Effect of Obesity and Underweight Status on Perioperative Outcomes of Congenital Heart Operations in Children, Adolescents, and Young Adults: An Analysis of Data from the Society of Thoracic Surgeons Database. Circulation, 136(8): 704-718. PMCID: PMC5731184.

O’Byrne ML, Glatz AC, Mercer-Rosa L, Gillespie MJ, Dori Y, Goldmuntz E, Kawut S, Rome JJ. 2015. Trends in Pulmonary Valve Replacement In Children and Adults with Tetralogy of Fallot. Am J Cardiol, 115(1): 118-124. PMCID: PMC4262614.