PHA/ATS Research Fellowship in Pulmonary Arterial Hypertension Grant Winner 2018

Soban Umar, M.D.

Assistant Professor-in-Residence
University of California, Los Angeles
Title: “miR-125b as a Novel Therapeutic Target in Pulmonary Hypertension Associated with Pulmonary Fibrosis”
Term: Dec. 1, 2018 – Nov. 30, 2020

Summary of Research Project:

Patients with pulmonary fibrosis are known to develop pulmonary hypertension through a poorly defined mechanism, resulting in increased morbidity and mortality and a need for lung transplant. In this proposal, we will first investigate the mechanisms by which pulmonary hypertension develops in pre-existing pulmonary fibrosis and study the novel techniques that target some of the key mechanistic players, so that we can develop the most effective therapies for preventing this fatal disease.

Curriculum Vitae

Education/Training

2009-2012 Postdoctoral Fellow, Department of Anesthesiology, UCLA

2012-2016 Resident Physician, Department of Anesthesiology, UCLA

June 30, 2016- Assistant Professor-In-Residence, Department of Anesthesiology, UCLA

Honors and Awards

2018 Winner of the UCLA DGSOM Travel Award

2017 Winner of the UCLA Cardiovascular Theme Innovation Award

2017 Winner of the Junior Faculty Research Award at Association of University Anesthesiologists (AUA) Meeting, Washington DC, USA

2016 Winner of the Best of Basic Science Abstract at the American Society of Anesthesiologists Conference, Chicago, IL, USA

2016 Best of Basic Science Abstracts (two abstracts out of 9 in the session) at the American Society of Anesthesiologists Conference, Chicago, IL, USA

2016 Best of Abstracts presentations at the International Anesthesia Research Society (IARS) Meeting, San Francisco, CA, USA

2016 Invited oral presentation at the Association of University Anesthesiologists (AUA) Meeting, San Francisco, CA, USA

2016 Winner of the hypothesis-based abstracts award, and the recipient of the ‘Leonard F. Walts, MD Research Excellence Award’ at the Annual Department of Anesthesiology Scientific Evening, at Ronald Reagan UCLA Medical Center

2015 Best of Basic Science Abstract at American Society of Anesthesiologists Conference, San Diego

2015 Invited speaker, OSSD Conference, Stanford University, Stanford, CA, USA

2015 Winner of the abstract scholarship award at American Thoracic Society Meeting, Denver

2015 Winner of the hypothesis-based abstracts award, recipient of the ‘Leonard F. Walts, MD Research Excellence Award’ UCLA Department of Anesthesiology Scientific Evening

2015 Winner of the second-place oral presentation prize at WARC 2015 Meeting, Seattle, WA,

2014 Recipient of the UCLA Olive View ‘Resident of the Year’ Award at the Annual Resident Graduation ceremony at UCLA, Los Angeles, CA, USA

2014 Recipient of ‘FAER Resident Scholar’ Award for American Society of Anesthesiologists Annual Conference, New Orleans, LA, USA

2014 Winner of the top scoring research-based poster presentation in clinical or basic science receiving ‘The White Mountain Research Award’ at the WARC 2014 Meeting in Los Angeles, CA, USA

2014 Best of Basic Science Abstract at the American Society of Anesthesiologists Conference, New Orleans, LA, USA

2014 Winner of the hypothesis-based abstracts award, and the recipient of the ‘Leonard F. Walts, MD Research Excellence Award’ at the Annual Department of Anesthesiology Scientific Evening, at Ronald Reagan UCLA Medical Center

2014 Invited Facilitator for thematic poster session at American Thoracic Society Meeting, San Diego

2013 Winner of the hypothesis-based abstracts award at the Annual Department of Anesthesiology Scientific Evening, at Ronald Reagan UCLA Medical Center

2013 Invited Facilitator/Moderator for thematic poster session at American Thoracic Society Meeting, Philadelphia, PA, USA

2013 Winner of the abstract scholarship award at American Thoracic Society Meeting, Philadelphia, PA

2012 Nominated for ‘UCLA Chancellor’s Award for Postdoctoral Research’, Los Angeles, CA

2012 Oral presentation American Society of Anesthesiologists Conference, Washington DC

2012 Oral presentation American Thoracic Society Meeting, San Francisco, CA, USA

2012 Recipient of the Young Investigator Award American Heart Association Annual Conference, Resuscitation Science Symposium, Los Angeles, CA, USA

2012 Young Investigator Travel Award American Thoracic Society Conference, San Francisco, CA, USA

2012 Oral presentation Biophysical Society Meeting, San Diego, CA, USA

2011 Oral presentation American Society of Anesthesiologists Conference, Chicago, IL, USA

2011 Best of Basic Science Abstract American Society of Anesthesiologists Conference, Chicago, IL

2011 Oral presentation American Thoracic Society (ATS) Annual Conference, Denver, CO, USA

2011 Young Investigator Travel Award American Thoracic Society Conference, Denver, CO

2011 Poster award at UCLA Department of Medicine Research Day, Los Angeles, CA, USA

2010 Oral presentation American Heart Association (AHA) Scientific Sessions, Chicago, IL, USA

2010 Young Investigator Travel Award from 3CPR council of American Heart Association (AHA) Annual Scientific Sessions, Chicago, IL, USA

2010 Abstract awarded as Best of Basic Science at AHA BCVS Meeting, Rancho Mirage, CA,

2007 Oral presentation American Heart Association (AHA) Scientific Sessions, Orlando, FL, USA

2002 First position (Honors, Gold Medal) in the Final Professional M.B.B.S Examination in Nishtar Medical College and Bahauddin Zakariya University Multan, Pakistan

Research Support

2016-2018: Foundation for Anesthesia Education and Research (FAER) Mentored Research Training Grant

2017-2018: UCLA Cardiovascular Theme Innovation Award

Selected Publications

Umar S., Cunningham C, Itoh Y, Moazeni S, Vaillancourt M, Sarji S, Centala A, Arnold AP, Eghbali M (2017). The Y Chromosome Plays a Protective Role in Pulmonary Hypertension. Am J Respir Crit Care Med. doi: 10.1164/rccm.201707-1345LE. (Accompanied by Editorial, and Press Release)

Umar S., Iorga A., Matori H., Nadadur R.D., Li J., Maltese F., Eghbali M. (2011). Estrogen rescues severe pulmonary arterial hypertension. Am J Respir Crit Care Med.;184: 715-723. PMCID: 3208600. (Journal Cover, Accompanied by Editorial and Press Release)

Sharma S., Umar S., Potus F., Iorga A., Wong G., Meriwether D., Breuils-Bonnet S., Mai D., Navab K., Ross D., Navab M., Provencher S., Fogelman A.M., Bonnet S., Reddy S.T. & Eghbali M. (2014). ApoA-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p. Circulation. 130(9):776-85. PMCID: 4194270. (Accompanied by Press Release).

Umar S., Iorga A., Matori H., Nadadur R.D., Li J., Maltese F., Eghbali M. (2011). Estrogen rescues severe pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine;184: 715- 723. PMCID: 3208600. Journal Cover. Accompanied by an editorial entitled “Making Sense of the Estrogen Paradox in Pulmonary Arterial Hypertension”. The significance of the work has also been summarized in a “UCLA Newsroom” article entitled “Estrogen treatment may help reverse severe pulmonary hypertension”. http://newsroom.ucla.edu/portal/ucla/estrogen-treatment-may-help-reverse-215186.aspx

Umar S., Rabinovitch M., Eghbali M. (2012). Estrogen Paradox in Pulmonary Hypertension: Current Controversies and Future Perspectives. Am J Respir Crit Care Med. 186(2):125-31. PMCID: PMC3406082.

Umar S., Partow-Navid R., Ruffenach G., Iorga A., Moazeni S., Eghbali M (2017). Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy. Biol Sex Differ. 2017 Mar 20;8:9. doi: 10.1186/s13293-017-0129-7.

Sharma S., Umar S., Potus F., Iorga A., Wong G., Meriwether D., Breuils-Bonnet S., Mai D., Navab K., Ross D., Navab M., Provencher S., Fogelman A.M., Bonnet S., Reddy S.T. & Eghbali M. (2014). ApoA-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p. Circulation. 130(9):776-85. PMCID: 4194270. Accompanied by news release. http://newsroom.ucla.edu/releases/proteinin-good-cholesterol-may-be-a-key-to-treating-pulmonary-hypertension

Sharma S, Ruffenach G, Umar S, Motayagheni N, Reddy ST, Eghbali M (2016). Role of oxidized lipids in pulmonary arterial hypertension. Pulm Circ. 2016 Sep;6(3):261-73.

Umar S., Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M (2011). Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats. Hypertension. 2011 Sep;58(3):512-8.

Rahman S., Li J., Bopassa J.C., Umar S., Ciobotaru A., Partownavid P., Eghbali M. (2011). Phosphorylation of GSK-3b mediates Intralipid-induced cardioprotection against Ischemia/Reperfusion injury. Anesthesiology;115(2):242-53. PMCID: 3322241. Accompanied by an editorial view entitled “From Local to global, Lipid emulsion makes the move”. Highlighted with a press release from Anesthesiology Journal and is summarized in a “UCLA News Release” article, entitled “UCLA study shows man-made fat may limit damage to heart attack victims”. http://newsroom.ucla.edu/portal/ucla/ucla-study-shows-good-fats-may-211515.aspx?link_page_rss=211515

Li J, Ruffenach G, Kararigas G, Cunningham CM, Motayagheni N, Barakai N, Umar S, Regitz-Zagrosek V, Eghbali M (2017). Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway. J Mol Cell Cardiol. 2017 Jan;102:108-116.

Umar S, Li J, Hannabass K, Vaillancourt M, Cunningham CM, Moazeni S, Mahajan A, Eghbali M (2018). Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection. Anesthesiology. 2018 May 10. doi: 10.1097/ALN.0000000000002195. Highlighted with a a “UCLA News Release” article, “Study identifies receptor that may be targeted to repair the heart after heart attack, cardiac arrest”

Umar S., Cunningham C, Itoh Y, Moazeni S, Vaillancourt M, Sarji S, Centala A, Arnold AP, Eghbali M (2017). The Y Chromosome Plays a Protective Role in Pulmonary Hypertension. Am J Respir Crit Care Med. doi: 10.1164/rccm.201707-1345LE. [Epub ahead of print] PMID: 28934553. http://newsroom.ucla.edu/releases/genes-on-y-chromosome-protect-against-pulmonary-hypertension-studysuggests

Li J., Chen X., McClusky R., Ruiz-Sundstrom M., Itoh Y., Umar S, Arnold A.P., Eghbali M. (2014). The number of X chromosomes influences protection from ischemia/reperfusion injury in mice: One X is better than two. Cardiovascular Research 102:375-84 PMCID: PMC4030514.

Li J., Umar S. Iorga A., Youn J.Y., Wang Y., Regitz-Zagrosek V., Cai H., Eghbali M. (2012). Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy. Basic Research in Cardiology;107(4):271. PMCID: 3769136. The significance of this work was highlighted in UCLA News Release entitled “UCLA study looks at why heart attacks cause so much more damage in late pregnancy” http://newsroom.ucla.edu/portal/ucla/ucla-study-demonstrates-cardiac 235535.aspx

Umar S., Nadadur R.D., Iorga A., Amjedi M., Matori H., Eghbali M. (2012). Cardiac structural and hemodynamic changes associated with physiologic heart hypertrophy of pregnancy are reversed postpartum. The Journal of Applied Physiology;113(8):1253-9. PMCID: PMC3472485.