Proof of Concept Winners 2017-05-25T20:45:02+00:00

PHA Proof of Concept Award Winners

This grant’s target audience is investigators who are interested in early-stage pulmonary hypertension research.

This program supports new research projects that are in the early exploratory and developmental stages and have the potential to lead to advances in the scientific understanding of PH. Proposed projects result in preliminary data that will enable the investigator to apply for support for a larger, hypotheses-driven research project.

As of 2014, PHA has supported 13 researchers through this partnership and we hope to continue to further our understanding of PH by continuing to support such novel efforts in the field.

2016

Kazuyo Kegan, PhD Kazuyo Kegan, PhD

“Illuminating AMPK function in crosstalk between Insulin Resistance and Pulmonary Hypertension”
December 1, 2016- November 30, 2017
Assistant Professor
Anesthesiology and Critical Care Medicine
Johns Hopkins University
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2015

Ke Yuan, PhD Ke Yuan, PhD

“The role of lung pericytes as a source of occluding pulmonary artery smooth muscle cells in PAH”
December 1, 2015- November 30, 2016
Instructor, Pulmonary Critical Care Medicine
Stanford University
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Soban Umar, MD, PhD Soban Umar, MD, PhD

“Y Chromosome confers protection against pulmonary arterial hypertension”
December 1, 2015 – November 30, 2016
Resident Physician, Molecular Medicine
University of California Los Angeles
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The Jerry Wojciechowski PH Proof of Concept Grant

2014

Daniel L. Fox, MD Daniel L. Fox, MD

“SSc-PAH Risk Score: Early Identification of Scleroderma-associated PAH by RV Strain, GDF-15 & IL&r”
December 1, 2014 – November 30, 2015
University of Colorado Denver
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Frances S. de Man, PhD Frances S. de Man, PhD

“A New Tool to Obtain Novel Insights in PAH-Induced Right Heart Failure”
December 1, 2014 – November 30, 2015
VU University Medical Center Amsterdam
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The Jerry Wojciechowski Pulmonary Hypertension Proof of Concept Grant

Fiona Murray, PhD Fiona Murray, PhD

“A novel G-protein coupled receptor (GPCR) target in pulmonary arterial hypertension”
January 15, 2015 – January 14, 2016
University of Aberdeen, UK
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American Thoracic Society Foundation/Pulmonary Hypertension Association Proof of Concept Research Grant

Marc de Perrot, MD, MSc Marc de Perrot, MD, MSc

“Photodynamic therapy for the treatment of pulmonary arterial hypertension”
December 1, 2014 – November 30, 2015
University of Toronto, Canada
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2013

Evan L. Brittain, MD Evan L. Brittain, MD

“Cardiac Steatosis and Right Ventricular Failure in Pulmonary Arterial Hypertension”
December 1, 2013 – November 30, 2014
Vanderbilt University School of Medicine, Nashville, Tenn.
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Jiwang Chen, PhD Jiwang Chen, PhD

“Role of IL7/IL7R in the Pathogenesis of Pulmonary Arterial Hypertension”
December 1, 2013 – November 30, 2014
University of Illinois at Chicago, Chicago, Ill.
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Kylie M. Drake, PhD Kylie M. Drake, PhD

“Pharmacological Correction of BMP Signaling by Read-Through in Pulmonary Arterial Hypertension”
December 1, 2013 – November 30, 2014
The Cleveland Clinic Foundation, Cleveland, Ohio
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The Jerry Wojciechowski Pulmonary Hypertension Proof of Concept Grant

Nicole M. Pohl, PhD Nicole M. Pohl, PhD

“Role of miR-181b in the Regulation of TRPC6 and the Development of Pulmonary Hypertension”
December 1, 2013 – November 30, 2014
University of Illinois at Chicago, Chicago, Ill.
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Yen-Rei Yu, MD, PhD Yen-Rei Yu, MD, PhD

The Role of Resident Monocytes in the Pathogenesis of Pulmonary Arterial Hypertension
January 15, 2014 – January 14, 2015
Duke University School of Medicine, Durham, N.C.
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2012

Michael Yeager, PhD Michael Yeager, PhD

Unfolded Protein Response Confers Apoptosis Resistance and Inflammation in Pulmonary Hypertension
December 1, 2012 – November 30, 2013
University of Colorado Health Sciences Center, Denver
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Guofei Zhou, PhD Guofei Zhou, PhD

AMPK and Pulmonary Arterial Hypertension
December 1, 2012 – November 30, 2013
University of Illinois College of Medicine, Chicago
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2011

Mary Beth Brown, PhD, PT, ATC Mary Beth Brown, PhD, PT, ATC

Clinical Investigation of a Daily Walking Program plus L-Arginine Supplementation for the Treatment of Pulmonary Arterial Hypertension
October 1, 2011 – September 30, 2012
Indiana University, Indianapolis
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Ferhaan Ahmad, MD, PhD Ferhaan Ahmad, MD, PhD

Applying Genomics as a Springboard to Novel Mechanisms of Pulmonary Hypertension
October 1, 2011 – September 30, 2012
University of Pittsburgh, Pittsburgh
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