PHA/Pfizer Proof of Concept Research Grant Winner 2011

Ferhaan Ahmad, MD, PhDFerhaan Ahmad, MD, PhD

Departments of Medicine and Human Genetics
University of Pittsburgh, Pittsburgh
Title: “Applying Genomics as a Springboard to Novel Mechanisms of Pulmonary Hypertension”
Term: October 1, 2011 and will end September 30, 2012

Summary of Research Project:

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by abnormal thickening of blood vessel walls. Even with the best treatments, only about half of patients survive five years after diagnosis. This project will analyze the molecular and cellular pathways that different lung blood vessel cells follow to become abnormal in PAH, and identify new treatments that reverse these pathways and possibly cure patients. To accomplish this goal, we plan to study blood vessels from lungs removed from patients with PAH at the time they are undergoing lung or heart-lung transplant operations.

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by abnormal thickening of blood vessel walls. Even with the best treatments, only about half of patients survive five years after diagnosis. This project will analyze the molecular and cellular pathways that different lung blood vessel cells follow to become abnormal in PAH, and identify new treatments that reverse these pathways and possibly cure patients. To accomplish this goal, we plan to study blood vessels from lungs removed from patients with PAH at the time they are undergoing lung or heart-lung transplant operations.