PHA/Pfizer Proof of Concept Research Grant Winner 2011

Mary Beth Brown, PhD, PT, ATC

Mary Beth Brown, PhD, PT, ATC

Department of Physical Therapy, School of Health and Rehabilitation Sciences
Indiana University, Indianapolis
Title: “Clinical Investigation of a Daily Walking Program plus L-Arginine Supplementation for the Treatment of Pulmonary Arterial Hypertension”
Term: October 1, 2011 and will end September 30, 2012

Summary of Research Project:

We are investigating if functional and biochemical indicators of disease progression are attenuated in patients with pulmonary arterial hypertension (PAH) by 12 weeks of daily aerobic exercise plus dietary supplementation of L-arginine, an amino acid important to vascular health. Training will consist of a simple walking program- 3 supervised treadmill sessions and 3 unsupervised home walking sessions per week at moderate intensity for 45 minutes. Supervised exercise and testing will be performed at the National Institute of Fitness and Sport (NIFS) on the IU School of Medicine campus. During home walking sessions, adherence to prescribed exercise parameters will be facilitated with the use of personal heart rate monitors with data upload capability. A relatively small number of subjects will be enrolled in this initial ‘proof-of-concept’ project so that feasibility, efficacy, and safety of the research plan may be assessed in a timely and economical manner. Findings will be used in the planning of a clinical trial of exercise and supplemental L-arginine in a large study population.e American College of Sports Medicine, so that nutritional guidance can be better provided for these individuals by their health care providers.