Pulmonary Vascular Disease Phenomics (PVDomics)
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics is a multi-center initiative to understand individual differences among people with pulmonary hypertension. By identifying biomarkers, the PVDomics project aims to improve PH diagnosis and treatment.
The observational study was funded by the National Heart, Lung and Blood Institute with support from the Pulmonary Hypertension Association. Researchers collected information from about 1,000 people with various types of PH and 500 people without or at risk for PH.
The study performed comprehensive phenotyping for all types of PH. Since then, researchers have published more than 20 papers based on data from the study. See links to PubMed abstracts.
The projects hopes to deconstruct traditional PH classifications and define new sub-groups of PH. Ideally, the new sub-classifications would lead to more targeted screening and personalized approaches for treatment, care and prevention of pulmonary vascular disease.
Participating centers
Cleveland Clinic (data coordinating center)
Brigham and Women’s Hospital, Boston
Jane A. Leopold, MD, principal investigator
Columbia University-New York Presbyterian
Erika S. Berman Rosenzweig, MD, principal investigator
Weill Cornell Medicine-New York Presbyterian
Evelyn Horn, MD, principal investigator
Johns Hopkins University
Paul Hassoun, MD, principal investigator
Mayo Clinic
Robert P. Frantz, MD, principal investigator
University of Arizona
Franz Rischard, DO, principal investigator
Vanderbilt University
Anna Hemnes, MD, principal investigator
More information
PHA interview with Jane Leopold
Study protocol (Cleveland Clinic)
Related content
New Papers Show How PVDomics Is Redefining PH Classifications