Key takeaways about bosentan

Bosentan is approved for children and teens ages 3 years and older. This medication treats pulmonary arterial hypertension, also known as Group 1 pulmonary hypertension. The goal of this medication is to improve exercise ability and slow disease progression. 

Tracleer was the first pill the Food and Drug Administration approved for PAH in 2001. Generic versions also are available. 

The pediatric formulation of bosentan is designed to help children adhere to their medication routine. It is a fruit-flavored “melt-in-the-mouth” or easily dissolved 32 mg pill.

Tips for easy swallowing:

  • Break the tablet in half along the line. Don’t break into quarters.
  • Dissolve tablets in a minimal amount of water (in a spoon) right before giving to your child.

The dosage is typically based on the patient’s weight. The patient’s physician will determine the proper dose.

Bosentan is generally well tolerated. Common side effects include:

  • Sinus/lung congestion or infection
  • Flushing
  • Headache
  • Increased liver enzymes
  • Swelling of the hands and feet (fluid retention)

Information for school staff

The student might need to be absent from school for mandatory monthly blood tests to monitor this medication. 

Call the parent/student’s physician immediately if the student experiences: 

  • Nausea 
  • Vomiting 
  • Fever 
  • Unusual tiredness 
  • Abdominal pain 
  • Yellow/orange of the skin or eyes 

Paying for your child’s medication

Most insurance pays for part of this medication, but some plans have high out-of-pocket costs. Depending on your plan, you might qualify for financial assistance from J&J, which makes Tracleer, or a nonprofit organization.

Explore financial assistance options

Updated September 2025